Resveratrol is a natural compound with antioxidant properties, found in foods like red wine, grapes, berries, and peanuts. It is most concentrated in the skins and seeds of grapes, which is why red wine contains higher amounts. Resveratrol has gained attention for its potential role in slowing aging and protecting against conditions like cancer, heart disease, obesity, and diabetes.

Is this used to correct a deficiency or achieve supramaximal levels?

Supramaximal

Is it taken for life span or health span?

Healthspan

Is it targeting a specific disease? Or general health?

General health, CDV and diabetes

Any genetic involvement?

N/A

Is there a biomarker to track its effects?

N/A

MOA of supplement

Resveratrol acts as a powerful antioxidant by neutralizing free radicals and reducing oxidative stress. It also inhibits inflammatory pathways, such as NF-κB, and activates key cellular regulators like AMPK and SIRT1, which enhance mitochondrial function, glucose metabolism, and lipid balance. Through these actions, Resveratrol is protective against chronic diseases including cardiovascular disease, diabetes, obesity, and neurodegenerative conditions like Alzheimer's.

Risk vs reward

+ Anti-inflammatory and antioxidant properties, protects against reactive oxygen species

+ Reduce inflammation and inhibits platelet aggregation which may prevent atherosclerosis

+ May have chemoprotective agents

+ Reduces expression and activation of COX 1 and 2 which are involved in inflammatory conditions

+ May aid in weight loss

- Liquid form, at low pH and temperature and at limited exposure to oxygen and light

- Low bioavailability (not easy to absorb) and rapid metabolism (excreted quickly)

- In certain doses, resveratrol can act as a pro-oxidant leading to DNA and cellular damage and apoptosis

- It can also interact with many drugs making them more or less potent

- High dose is associated with GI problems and can cause hypersensitivity in some individuals and nephrotoxicity Low doses are beneficial and high doses are toxic

Evidence for it?

Review of clinical trials shows that Resveratrol reduces the activity of certain genes related to breast cancer, like RASSF1A. In diabetic patients, it helps improve insulin sensitivity and lower blood sugar levels. It may also be cardioprotective for various cardiovascular conditions, though it may be less effective in people who are severely overweight.

Systematic review and meta analysis Resveratrol has the potential to reduce inflammation in people with cardiovascular diseases (CVDs). A review of six studies found that resveratrol helped lower two key markers of inflammation, CRP and TNF-α. However, it didn’t significantly affect another marker, IL-6. These results suggest that resveratrol could help manage inflammation in CVD patients, but more research is needed to confirm how effective it really is.

Systematic review of 19 studies found that resveratrol supplementation did not significantly impact weight loss. While a small improvement in waist circumference was observed, only three studies showed positive effects on weight-related outcomes. One of these studies saw significant results only when resveratrol was combined with orlistat, a weight loss drug. Overall, the findings suggest that resveratrol alone does not have a significant anti-obesity effect, and the limited number of studies makes it difficult to draw definitive conclusions.

RCT This study assessed the impact of 6 months of 150 mg/day resveratrol supplementation on metabolic health in overweight individuals. 41 participants were randomly assigned to resveratrol or placebo. Insulin sensitivity showed no significant differences between groups. However, HbA1c levels were significantly lower in the resveratrol group. No changes were observed in liver fat, body composition, blood pressure, or physical performance. The findings suggest that while resveratrol reduced HbA1c, it did not improve insulin sensitivity, and higher doses may be needed for more significant effects.this 12-week randomised, placebo-controlled trial, ashwagandha (200 mg twice daily) did not significantly reduce perceived stress compared to placebo in overweight or mildly obese adults with high stress. However, it significantly reduced fatigue, increased heart rate variability, and in men, boosted free testosterone and luteinizing hormone levels. Ashwagandha was well-tolerated, suggesting potential anti-fatigue and hormonal benefits.

Evidence against it?

Systematic review and meta-analysis evaluated the effects of resveratrol supplementation on metabolic health in overweight or obese individuals. The results showed no significant improvements in key health markers like cholesterol, blood sugar, liver enzymes, or BMI. Despite some positive trends, the changes were not clinically meaningful. These findings suggest that resveratrol may not be an effective standalone treatment for obesity-related conditions, and further research is needed to explore its potential benefits.

RCT This study evaluated the effects of high-dose resveratrol on metabolic health in 24 obese men over 4 weeks. The results showed no significant improvements in insulin sensitivity, glucose production, lipid oxidation, blood pressure, or fat content. Additionally, there were no changes in gene expression related to metabolism or inflammation. These findings contradict previous studies showing positive effects with lower doses of resveratrol. The study suggests that resveratrol may not effectively improve metabolic health in individuals with mild insulin resistance.

Systematic review of 19 studies found that resveratrol supplementation did not significantly impact weight loss. While a small improvement in waist circumference was observed, only three studies showed positive effects on weight-related outcomes. One of these studies saw significant results only when resveratrol was combined with orlistat, a weight loss drug. Overall, the findings suggest that resveratrol alone does not have a significant anti-obesity effect, and the limited number of studies makes it difficult to draw definitive conclusions.

Best bioavailable form?

Powder/Micronized

Advice on taking it?

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Resveretrol